The number of non-itchy keloids was too small to enable a meaningful statistical comparison to be made. There was no evidence of a difference in nerve density in the papillary dermis and there was no difference in the distribution of nerves between keloids and controls.
There were no differences in nerve fiber density and distribution in the epidermis between the central and peripheral regions of the keloids.
Percentage PGP 9. Mean percentage PGP 9. Previous studies have found that epidermal innervation density is reduced in various pruritic conditions, such as lichen amyloidosis 5 , prurigo nodularis 6 , and discoid eczema 7.
Similarly, in this study, a trend towards a lower epidermal nerve density was found in keloids that are itchy. A hypothesis for these observations may be that chronic stimulation of itch-transmitting nerve fibers results in a self-regulated hypoplasia to modulate the intensity and persistence of sensory input. A reduction in nerve fiber density in the epidermis, where itch-conducting nerve fibers terminate, may therefore be a consequence of chronic pruritus and this phenomenon is generally not observed in the dermis.
This observation of likely reduced epidermal nerve fibers also supports our previous study which demonstrated abnormal sensory testing in keloids 1 , indicating the presence of small-fiber neuropathy in the disease.
In this study, no correlation between the innervation density of the keloidal skin and the intensity of itch and pain was found. This suggests that the difference in nociceptive sensations experienced in keloids is not due to the difference in the degree of neuronal innervation. Hypertrophic scars, like keloids, are form of pathological scar and the density of nerve fibers in them were found to be increased in previous studies 8, 9.
In a recent study, a greater number of nerve fibers were similarly found in keloids, but these fibers were located deeper in the skin In addition, it was found that those fibers were longer and thinner 10 , possibly be due to compression from the thickened and dense collagen fibers and excessive deposition of extracellular matrix in keloids. Background: Keloid scars can itch and hurt, but little is known about the characteristics of these symptoms in keloids.
Because itch and pain are carried by small nerve fibers, abnormal function of these fibers could be an explanation for such phenomena. Objective: We sought to assess the characteristics of itch and pain in keloid scars, and to assess the function of small nerve fibers in keloids. This cream is used to treat a variety of skin lesions, including superficial basal cell skin cancers.
It appears to work well on the skin after a keloid has been removed. A review in the Journal of Oral and Maxillofacial Surgery found that the cream reduced the chances of a keloid coming back. A newer treatment that is showing promising results involves a short course of radiation therapy , which is given immediately after surgically cutting out the keloids.
Several studies in the plastic surgery and dermatology literature show a high rate of cure, or at least improvement, in keloid scars in people treated by this method. Because keloids are difficult to treat, it is best to take steps to prevent them immediately after an injury, surgery, or piercing. People who are prone to keloids may wish to avoid tattoos and piercings altogether. If someone requires surgery for any reason, they should make their doctor aware of any history of keloids so prevention can begin soon after the surgery.
Though keloids do not pose a health risk, they can be emotionally and mentally damaging. Some treatments are available, but no single treatment works for all. People will need to discuss keloid removal options with their doctor and determine the best course of action to take. Hypertrophic scars are raised, red scars that occur due to collagen imbalance at the location of an injury.
Scars form when skin wounds heal. They often fade over time but can leave a permanent mark. Get some tips on preventing scars or making them less…. Treating burn scars depends on the severity of the burn and how recently it occurred.
The article examines the various types of burn scars, how to…. How do you get rid of keloids? Medically reviewed by Catherine Hannan, M. Why are keloids an issue? Causes Keloids and piercings Home remedies Medical treatments Outlook We include products we think are useful for our readers. Share on Pinterest Unlike most scars, keloids do not regress over time. Keloids and piercings. Share on Pinterest Using non-metal earing backs may help to prevent keloids from forming after ear piercing.
Home remedies. Medical treatments. Share on Pinterest Temporarily freezing tissues with cryotherapy may help to reduce the appearance of keloids. Latest news Scientists identify new cause of vascular injury in type 2 diabetes. Adolescent depression: Could school screening help?
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